There is no one best way to set up Google AdWords for everyone. Location, product, service, demographics, budget, etc....all factor into the success of a Google account and into the best way to set it up.
My best regional clients are in high traffic states like NY, NJ, CA, TX, FL. There are others that do well depending on what they offer.
Over the last couple of days, I've had several conversations with clients and potential clients about how quickly the Internet changes and my belief is that the next change will be more geared towards the regional/local market. It's moving that way now but I think there will be entirely new technology and shifts in advertising soon that will greatly impact how people market on the Internet.
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